The Stress and Learning Study

About the Study

Researchers at the San Francisco VA Medical Center are measuring the effectiveness of medications on responses to a laboratory task in people with and without symptoms of Posttraumatic Stress Disorder (PTSD).  In this study, participants will be asked to complete a simple learning and memory task by computer that involves a mild electrical pulse and will take a single dose of one of the medications (Hydrocortisone or D-Cycloserine) or a placebo (non-active) pill one time prior to one of the computer learning sessions.

 

We believe that this study will advance our understanding of service-related stress in veterans returning from service and that these findings may help us develop better treatments in the future. Our goal is to demonstrate that Hydrocortisone and DCS can improve stress responding during a task.

You may be eligible if you are

  • Male or Female between the ages of 18-65
  • Experienced a life threatening event
  • Meet other study criteria

Getting Started

As a potential participant, you will have a five to ten minute phone interview to determine your current eligibility. Eligible candidates will be invited for a paid clinical interview and medical examination.

Participation

If the clinical interview and medical examination confirm eligibility, qualified candidates will be offered the option of participating in the study. All participants will complete a computerized learning task over 4 appointments.  In addition, participants will be randomly selected to receive either Hydrocortisone, D-cycloserine, or a placebo prior to one of the appointments.

Compensation

Study participants will receive reimbursement up to $155 depending on the number of assessments completed.