The RISE Study

The purpose of this study is to examine the effects of an investigational sleep aid in comparison to a different type of sleep medication (ambien) or no medication at all (placebo). We are specifically interested in how these sleep inducing medications may affect a person’s thinking  when kept awake.

 To test this, volunteer participants will be given one dose of a study medication during the day. Rather than going to sleep as they normally would after taking a sleep aid, they will be asked to remain awake and perform a series of games and tasks designed to determine the drugs effect on their thinking, attention, coordination, and level of alertness.

If you believe you can out-shine the effects of the medication and perform well despite being sleepy, contact our study team at We will be happy to send you more information.

Why is this study being done?

Researchers at the Stress and Health Research Program are dedicated to advancing scientific understanding of the role of sleep in maintaining physical and psychological health.  Our goal is to see whether this investigation al medication produces similar effects on thinking and motor skills as compared to other prescription sleep aids.

Who can Participate?

To participate you must be:

-Between the ages of 19-39


-Have healthy sleep habits with consistent bedtimes and wake times

-Maintain a healthy weight

-Meet our other study criteria

Getting started


Please provide your full name, telephone number and the time that is best to reach you by phone.

We will ask you some questions over the phone which takes about 30 min, and if you are a potential match for the study, we will invite you for an in-person meeting and evaluation.

How long will I be in the Study?

To finish all of the procedures may take 2-3 visits spread over a few weeks. This includes the time you spend being interviewed by the mental health clinician, filling out a questionnaire booklet, getting lab-work done and signing paper work. The study itself is 10 days long and involves 7 days at home plus a 3 night, 2 day stay in our clinic at UCSF medical center. 

Will I be paid for my participation?

In return for your time and effort you will receive $625 dollars for completing all study procedures.  We also reimburse for travel expenses up to 35 $ per trip in.

Participants Come First

We are committed to the privacy and comfort of research participants throughout the course of the study. If you are interested in participating, please do not hesitate to contact us with questions via email or telephone.  All communications with our research staff are kept confidential.