A.F.T.E.R Study

Analyzing Female Trauma Exposed Responses to a Medication

Seeking Women with Post Traumatic Stress


The Stress and Health Research Program at the San Francisco VA is committed to improving the diagnosis and treatment of PTSD/PTS. The purpose of this study is to test the effectiveness of an investigational medication for the treatment of Post-Traumatic Stress Disorder symptoms in women.

  Who is eligible?

Participants must be between 18 and 65 years old and:

Have symptoms of PTSD/PTS for at least 3 months

Symptoms include:

  • Experiencing nightmares and distressing thoughts about the traumatic event
  • Feeling tense, on-guard, and easily startled
  • Avoiding situations, people or places that remind you of the traumatic event
  • Feeling irritable and easily angered, often about everyday things
  • Difficulty concentrating, feeling nervous or jumpy, or
  • Experiencing relationship difficulties.

Are not substance abusers (do not overuse drugs or alcohol)

Meet other eligibility criteria

  Why is the study being done?

Researchers at the Stress and Health Research Program are dedicated to advancing scientific understandings of how trauma impacts health. This study, sponsored by the National Institute of Mental Health, compares an investigation medication thought to act on the hypothalamic-pituitary-adrenal axis (which controls the body’s stress response system) versus a placebo pill.

 How long will I be in the study?

Study duration is approximately 12 weeks, and all visits occur at The San Francisco VA medical center

 Getting Started?

You Can take this Survey or call us at 415 221 4810 ext. 4849


We will ask you some questions over the phone, and if you are a potential match for the study, we will invite you for an in-person meeting and evaluation.

 Will I be compensated?

Both the stress and health research program and the San Francisco VA value our participants contribution to the research process. In return for your time and effort you will receive up to $1,045 (plus travel) for completing all study procedures.